+91 8617752708

European Journal of Nutrition & Food Safety, ISSN: 2347-5641,Vol.: 4, Issue.: 2 (April-June)

Original Research Article

Impact of Dietary Intervention on Selected Biochemical Indices of Inflammation and Oxidative Stress in Nigerians with Metabolic Syndrome: A Pilot Study

 

Sheu Kadiri Rahamon1, Mabel Ayebatonyo Charles-Davies1, Kehinde Sola Akinlade1, John Ayodele Olaniyi2, Adesoji Adedipe Fasanmade3, Oyediran Emmanuel Oyewole4, Mayowa Ojo Owolabi3, Jane Roli Adebusuyi5, Olufunke Olayemi Hassan5, Babatunde Muhammed Ajobo6, Maria Onomhaguan Ebesunun8, Kehinde Adigun7, Unyime Aniekpon Fabian1, Omolara Olutosin Popoola1, Wemimo Okunbolade1, Olatunbosun Ganiyu Arinola1* and Emmanuel Oluyemi Agbedana1

1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
2Department of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
3Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
4Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria.
5Medical Social Services Department, University College Hospital, Ibadan, Nigeria.
6Dietetics Department, University College Hospital, Ibadan, Nigeria.
7General out Patient Unit, University College Hospital, Ibadan, Nigeria.
8Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.

Abstracts

Aim: This study assessed the impact of dietary modification on cardiometabolic, inflammatory and oxidative stress indices in Nigerians with metabolic syndrome (MS).
Subjects and Methods: Sixty participants with MS were selected using the International Diabetes Federation criteria from a cohort participating in “Risk Assessment of Type 2 diabetes mellitus and Dementia in Nigerians with Metabolic Syndrome” study. The subjects were seen by a Dietitian and the approximate percentages of total calories from total protein, total fat, polyunsaturated fat, and carbohydrate were calculated from dietary history and pegged at 20%, 30%, 14% and 50% respectively. To ensure compliance, each participant was seen monthly (for 6 months) by the Dietitian. Glucose and lipid profile were determined using enzymatic methods. Serum activities of superoxide dismutase (SOD), catalase (CAT), Myeloperoxidase (MPO) and levels of nitric oxide (NO), malondialdehyde (MDA), hydrogen peroxide (H2O2), total protein and albumin were determined using spectrophotometric methods while high sensitivity C-reactive protein (hsCRP) and tumuor necrosis factor-alpha (TNF-α) were determined using ELISA. Student’s t-test (paired) and Wilcoxon signed-rank test were used for statistical analysis as appropriate. P-value <0.05 was considered significant.
Results: The mean blood pressure (BP), body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat, NO, hsCRP, H2O2, total protein and globulin were significantly reduced while the mean HDL, MDA, albumin and activities of CAT and MPO were significantly increased post-dietary modification compared with baseline.
Conclusion: Short-term dietary intervention improved cardiovascular risk, inflammation and oxidative stress indices in Nigerians with MS.

Keywords :

Cardiometabolic risk factors, dietary modification; high sensitivity C-reactive protein; inflammation; metabolic syndrome; oxidative stress.

Full Article - PDF    Page 137-149

DOI : 10.9734/EJNFS/2014/6604

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,
India

+91 8617752708

 

Third Floor, 207 Regent Street
London, W1B 3HH,
UK

+44 20-3031-1429