+91 8617752708

European Journal of Nutrition & Food Safety, ISSN: 2347-5641,Vol.: 9, Issue.: 1 (January-March)

Grey Literature

Risk Assessment of Specific Strains of Lactobacillus plantarum Used as "Other Substances"


Siamak Yazdankhah1*, Danica Grahek-Ogden1, Karl Eckner2, Georg Kapperud3, Jørgen Lassen1, Judith Narvhus4, Truls Nesbakken4, Lucy Robertson4, Jan Thomas Rosnes5, Olaug Taran Skjerdal2, Eystein Skjerve4, Line Vold3 and Yngvild Wasteson4

1Norwegian Scientific Committee for Food Safety (VKM), Norway.

2Norwegian Scientific Committee for Food Safety (VKM), Norwegian Veterinary Institute (VI), Norway.

3Norwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Public Health (FHI), Norway.

4Norwegian Scientific Committee for Food Safety (VKM), Norwegian University of Life Sciences (NMBU), Norway.

5Norwegian Scientific Committee for Food Safety (VKM), NOFIMA, Norway.

Article Information


(1) Dr. Morten Poulsen, Head of research group, Div. of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Denmark.

Complete Peer review History: http://www.sciencedomain.org/review-history/27750


The Norwegian Scientific Committee for Food Safety (Vitenskapskomiteen for mattrygghet, VKM) has, at the request of the Norwegian Food Safety Authority (Mattilsynet; NFSA), assessed the risk of "other substances" in food supplements sold in Norway. These risk assessments will provide NFSA with the scientific basis for regulation of the addition of “other substances” to food supplements and other foods.


"Other substances" are described in the food supplement directive 2002/46/EC as substances other than vitamins or minerals that have a nutritional and/or physiological effect. It is added mainly to food supplements, but also to other foods. VKM has not in this series of risk assessments of "other substances" evaluated any claimed beneficial effects from these substances, only possible adverse effects.

The present report is a risk assessment of Lactobacillus plantarum W62, Lactobacillus plantarum 299v and Lactobacillus plantarum HEAL9 based on previous risk assessments and also publications retrieved from literature search.


The risk of the Lactobacillus strains listed above was assessed for the general population. However, in previous assessments of probiotics published by VKM, concerns have been identified for specific groups. Therefore, the risk was assessed for the age group with immature gastro-intestinal microbiota (age group 0-36 months), population with mature gastro-intestinal microbiota (>3 years) and vulnerable groups with mature gastro-intestinal tract. VKM has also assessed the risk of L. plantarum W62, L. plantarum 299v and L. plantarum HEAL9 in food supplements and other foods independent of the dose and have assessed exposure in general terms.


VKM concludes that it is unlikely that L. plantarum W62, L. plantarum 299v and L. plantarum HEAL9 would cause adverse health effects in the general healthy population with mature gastro-intestinal tract.


However, no data on long-term adverse effects on infants and young children were identified. As evidence is accruing that the early microbial composition of the neonatal gut is important for the development of the gut microbiota and the immune system of the growing child, it is not possible to exclude that a daily supply of a single particular bacterial strain over a prolonged period of time to an immature gastro-intestinal tract may have long-term, although still unknown, adverse effects on that development.

Keywords :

Adverse health effect; negative health effect; Norwegian Food Safety Authority; Norwegian Scientific Committee for Food Safety; other substances; risk assessment; VKM; L. plantarum W62; L. plantarum 299v and L. plantarum HEAL9; food supplement.

Full Article - PDF    Page 28-29

DOI : 10.9734/EJNFS/2019/45636

Review History    Comments

Our Contacts

Guest House Road, Street no - 1/6,
Hooghly, West Bengal,

+91 8617752708


Third Floor, 207 Regent Street
London, W1B 3HH,

+44 20-3031-1429