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Journal of Pharmaceutical Research International, ISSN: 2456-9119, ISSN: 2231-2919 (past),Vol.: 25, Issue.: 2


Researching the Effects of Ellagic Acid on Depletion Exercise

Ersan Kara1, Funda Karabağ Çoban2* and Mustafa Akıl3

1Departmen of Coaching Training, Faculty of Sports Sciences, Alaaddin Keykubat University, Alanya, Turkey.

2Departmen of Molecular Biology and Genetics, Faculty of Science and Literature, Usak University, Uşak, Turkey.

3Department of Physical Education and Sports Training, Faculty of Sports Sciences, Usak University, Uşak, Turkey.

Article Information


(1) Dr. Barkat Ali Khan, Department of Pharmaceutics, Gomal University, Dera Ismail Khan, Pakistan.

(2) Dr. Jinyong Peng, Professor, College of Pharmacy, Dalian Medical University, Dalian, China.

(3) Dr. Ali Nokhodchi, Professor of Pharmaceutics and Drug Delivery, School of Life Sciences, University of Sussex, UK.


(1) Muhammad Shahzad Aslam, Xiamen University, Malaysia.

(2) Esraa Ashraf Ahmed El-Hawary, Ain Shams University, Egypt.

(3) Tushita Thakur, India.

Complete Peer review History: http://www.sdiarticle3.com/review-history/45923


Introduction: The purpose of this study was to investigate whether exhaustion exercise causes endothelial damage and to investigate the effect of ellagic acid on this potential damage.

Methods and Materials: The study was carried out on 32 male and adult Spraque - Dawley rats at Experimental Animal Research and Research Center of Afyon Kocatepe University. The experimental animals were equally divided into four groups. Swimming exercises will be performed as acute exercises for once and experimental animals are made to swim in groups including two rats following the completion of the study and before the decapitation. At the end of procedures that last for four weeks, total oxidant (TOS), total antioxidant (TAS), nitric oxide (NO) and Asymmetric dimethyl Arginine (ADMA), TNF α, INF γ and IL6 plasma and tissue levels was assayed from the blood samples to be taken from experimental animals with decapitation.

Results: The data obtained as a result of the studies were evaluated by using SPSS 20.0 statistical program. Endothelial damage markers and cytokine levels were significantly (p<0,05) increased in swimming groups and ellagic acid significantly (p<0,05)  decreased these parameters.

Conclusion: Ellagic acid  may have protective effect against damage that may occur during exhaustion exercise.

Keywords :

Rat; ellagic acid; endothelial damage.

Full Article - PDF    Page 1-8

DOI : 10.9734/JPRI/2018/45923

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